Possible role of muscle receptors in regulating arterial pressure during shifts in acid-base balance in muscles
Filippova, L.V.
Biulleten' Eksperimental'noi Biologii i Meditsiny 91(6): 647-649
1981
ISSN/ISBN: 0365-9615 PMID: 7272475 Document Number: 171737
It has been shown on anesthetized cats that perfusion of the gastrocnemius muscle with a solution simulating metabolic acidosis (pH 7.1, [HCO3-]-12.7 mM, PCO2- 38 mmHg) produces a threshold reflex increase in the arterial blood pressure. The relationship between the magnitude of the pressor reflexes and the decreased bicarbonate concentration and pH is depicted by a curve that consists of two areas: an initial progressive rise of the blood pressure is replaced after pH 6.6 by a more abrupt increase in the intensity of the pressor reflexes. The results indicate that the muscle receptors may take part in arterial blood pressure regulation during acid-base changes in the skeletal muscle.