The pharmacological blockade of the cardiac and gastric enteric ganglia by a new parasympatholytic
Remizov, I.M.; Berehova, T.V.; Hroĭsman, S.D.; Kharchenko, M.M.; Purnyn', O.E.; Skok, V.I.
Fiziolohichnyi Zhurnal 45(4): 61-68
1999
ISSN/ISBN: 2522-9028 PMID: 10474804 Document Number: 508457
The blocking effects of a newly synthetized compound N-decyltropine bromide (IEM-1556), on pentagastrin-, carbachol- and histamine-induced gastric secretion in chronic dogs, on stress-induced changes in gastric mucosa in rats, on vagus-induced effect in heart and on arterial blood pressure in rats were studied. The effects were compared with those produced by hexamethonium, a conventional ganglionic blocking agent. IEM-1556 inhibited gastric secretion and acid output for a much longer time than hexamethonium did. It also effectively protected gastric mucosa against stress-induced erosions and hemorrhages. IEM-1556 much more effectively blocked the vagus-induced reduction of the heart rate than hexamethonium did, and, in contrast to latter, did not reduce the arterial blood pressure. The results suggest that IEM-1556 is a highly selective blocking agent for parasympathetic and enteric ganglia versus sympathetic ganglia.