Effects of orally administered enteric-coated omeprazole on gastric acid secretion in horses
Andrews, F.M.; Doherty, T.J.; Blackford, J.T.; Nadeau, J.A.; Saxton, A.M.
American Journal of Veterinary Research 60(8): 929-931
1999
ISSN/ISBN: 0002-9645 PMID: 10451198 Document Number: 503630
Five healthy 8-year-old mixed-breed horses fitted with gastric cannulas were used to determine the effects of orally administered omeprazole, as enteric-coated capsules, on baseline and stimulated gastric acid secretion in horses. Enteric-coated granules of omeprazole were mixed with maize syrup and administered orally once daily for 5 consecutive days. On days 1 and 5 beginning 5 h after omeprazole administration, 4 gastric fluid samples were collected, each for 15 min, via the gastric cannula (baseline samples). Pentagastrin was administered i.v. as a constant infusion for the subsequent 2 h, and 15-min gastric fluid samples were again collected (stimulated samples). Compared with values obtained during control experiments, baseline and stimulated gastric fluid acidity and gastric acid production significantly decreased, and the mean pH of gastric fluid samples significantly increased, after administration of 5 daily doses of omeprazole. Enteric-coated omeprazole (1.0 mg/kg of body weight, p.o.) administered once daily for 5 days significantly inhibited unstimulated and pentagastrin-stimulated gastric acid secretion in horses. It is concluded that this commercial formulation of omeprazole may be efficacious in treating gastroduodenal ulcers in horses.