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Role of cortisol in the deterioration of glucose tolerance in Sudanese pregnant women

Ahmed, S.A.; Shalayel, M.H.

East African Medical Journal 76(8): 465-467

1999

ISSN/ISBN: 0012-835X
PMID: 10520355
Document Number: 507964
Objective: To study the state of insulin resistance which occurs in pregnancy and the possible role of cortisol in augmentation of this state. Design: Case-control study. Setting: Khartoum teaching hospital, Khartoum north hospital, Soba hospital, Ibrahim Malek hospital, maternity hospital and Fath-Elbasheer referral centre from January to August 1996. Subjects: Thirty pregnant women with gestational diabetes mellitus(GDM) and thirty pregnant women with impaired glucose tolerance(IGT) were compared with thirty control pregnant women with normal glucose tolerance. Results: The GDM and the IGT groups were found to have significantly higher levels of serum cortisol than that of the control group (937.2+-79.4 nmol/l (mean +- S.E.) and 794.2+-60.5 vs 597.3+-30.9 respectively, p < 0.0006). Conclusion: Cortisol has a great role to play in the deterioration of glucose tolerance in pregnancy.

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