Differences in postload plasma glucose levels between 100-g and 75-g oral glucose tolerance tests in normal pregnant women: a potential role of early insulin secretion
Soonthornpun, K.; Soonthornpun, S.; Thamprasit, A.; Aksonteing, J.
Journal of the Medical Association of Thailand 91(3): 277-281
2008
ISSN/ISBN: 0125-2208 PMID: 18575277 Document Number: 3423
Objective: To demonstrate a role of early insulin secretion on plasma glucose levels after different amounts of oral glucose loads in pregnant women.Material and Method. Forty-one pregnant women with normal glucose tolerance according to the Carpenter and Coustan's criteria and 25 non-pregnant women (control group) with normal glucose tolerance according to the World Health Organization criteria were enrolled Each subject was randomly scheduled to perform both the 100-g and 75-g OGTT within a 1-week interval, Venous blood was drawn at fasting, 30-, 60-, 120-, and 180-minute intervals during both tests for determination of plasma glucose and serum insulin levels.Results: The mean ( SE) ages of the pregnant and control groups were 33.3 +/- 0.9 and 31.8 +/- 1.4 years, respectively. The mean gestational age at the time of performing OGTT of the pregnant group was 28.7 +/- 0.6 weeks. In the non-pregnant group, the plasma glucose concentrations were not different between 75-g and 100-g OGTT whereas the serum insulin levels at the 30 and 180 minutes of the 100-g OGTTwere significantly higher than those of the 75-g OGTT In the pregnant group, both plasma glucose and serum insulin concentrations at the 120 and 180 minutes of the 100-g OGTT were significantly higher than those of the 75-g OGTTConclusion: The limited ability of early insulin secretion to increase when glucose load increased in the pregnant women could explain the high plasma glucose levels at 2 and 3 hours of 100-g OGTT compared to those of 75-g OGTT.
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