Postpartum glucose tolerance in women with gestational diabetes using levonorgestrel intrauterine contraception
Kiley, J.W.; Hammond, C.; Niznik, C.; Rademaker, A.; Liu, D.; Shulman, L.P.
Contraception 91(1): 67-70
2015
ISSN/ISBN: 1879-0518 PMID: 25193535 DOI: 10.1016/j.contraception.2014.08.004Document Number: 623215
Postpartum contraception is critical in women with gestational diabetes mellitus (GDM). We evaluated the effect of the levonorgestrel intrauterine system (LNG-IUS) on glucose tolerance in postpartum women with GDM. The study is a descriptive analysis of 12-month glucose tolerance in women with recent GDM who used the LNG-IUS, the copper IUD or postpartum sterilization. Twelve months postpartum, 3 of 13 LNG-IUS users (23.1%) and 1 of 6 nonhormonal contraceptive users (16.6%) had prediabetes. No woman developed overt diabetes. This study is the first and only to measure the metabolic effects of the LNG-IUS women with GDM. Larger trials are necessary. Use of levonorgestrel intrauterine contraception does not appear to negatively affect glucose tolerance in postpartum women with a history of gestational diabetes. Additional appropriately powered clinical studies are needed to confirm these results.
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