New breakpoints of t (9;22) translocation in chronic myeloid leukemia
Misiurin, A.V.; Surin, V.L.; Tagiev, A.F.
Bioorganicheskaia Khimiia 25(3): 234-236
1999
ISSN/ISBN: 0132-3423 PMID: 10382043 Document Number: 507239
Nine new breakpoints (junction sites) of the BCR and ABL genes in a chimeric oncogene BCR/ABL from translocation t(9;22) were studied in patients with chronic myeloleukemia. It was demonstrated for the first time that some breakpoints in these genes are identical in different patients. DNA fragments containing BCR/ABL breakpoints were amplified using the PCR walking technique. The approach, called reverse primer walk (RPW), is based on a modification of the PCR method with a random annealing of primers.
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