Effect of human plasma HDL on the HDL receptors of plasma membranes of cholesterol-fed rabbit
Wu, X.; Fu, M.; Lan, D.; Liu, B.; Zhou, J.; Deng, P.
Hua Xi Yi Ke da Xue Xue Bao 30(4): 370-372
1999
ISSN/ISBN: 0257-7712 PMID: 11387942 Document Number: 504488
Atherosclerosis(As) rabbit model was developed by high-cholesterol feeding for 12 weeks. The rabbits were injected intravenously with human plasma HDL preparation per week, and then the effects of HDL on the lipids contents of serum, liver and bile nd the activity of HDL receptors on liver plasma membranes of cholesterol-fed rabbit were investigated. The results showed that HDL preparation had no effect on decreasing the lipids contents of serum, but it could low down the lipid depositions in liver, and promote the excretion of lipids from bile. The value of Bmax of HDL receptor showed decreasing trendy and the value of Kd showed increasing trendy in cholesterol-fed rabbits. In HDL-treated rabbits, the value of Bmax increased significantly as compared with that of normal group(P < 0.05), but the value of Kd showed no difference. The results suggested that human plasma HDL could enhance the activity of HDL receptors on the liver plasma membranes of cholesterol-fed rabbit.