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Protein phosphorylation and activity of insulin and epidermal growth factor receptors in liver plasma membranes of rats kept in the zone of the accident at the Chernobyl nuclear power station

Bozhok, O.V.; BezdrobnyĭIuV; Kulik, G.O.; Serkiz, I.I.; Kartel', A.A.

Ukrainskii Biokhimicheskii Zhurnal 66(5): 35-39

1994

ISSN/ISBN: 0201-8470
PMID: 7747344
Document Number: 428578
Disruption in transfer of regulatory signal from insulin and EGF receptors in liver plasma membrane of rats, their 3 generation being kept in the Chernobyl accident 30-km zone has been found. As in case with imbalance in hormone binding and receptor phosphorylation of insulin receptors in experimental diabetes mellitus, an increasing of insulin and EGF binding by appropriate receptors with simultaneous decrease of its protein kinase activity after ligand binding was shown in rats chronically irradiated in the 30-km accident zone.

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