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Polychemotherapy-induced changes in the antioxidant state of blood in patients with inoperable cancer of the stomach

Frantsiiants, E.M.; Orlovskaia, L.A.; Shalashnaia, E.V.; Mucienko, N.V.; Anapalian, B.K.

Voprosy Onkologii 45(6): 607-611

1999

ISSN/ISBN: 0507-3758
PMID: 10703506
Document Number: 503934
Changes in antioxidant characteristics of blood in patients with inoperable tumors of the stomach were followed before and after combination polychemotherapy which comprised intraperitoneal and endolymphatic injection of drugs. General strengthening therapy was given prior to treatment. It was found that enzymatic activity as a component of antioxidant defenses offered by lymphocytes is low in such patients which adversely affects the structural and functional integrity of lymphocyte membranes. After chemotherapy, said function improved significantly showing a tendency towards normalizing. This effect correlated with clinical improvement and better quality of life in patients with inoperable gastric tumors.

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