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Structure-functional characteristics of heterodimeric phosphatidylinositol-3-kinase and molecular mechanisms of its conjugation with other components of the signaling system

Shpakov, A.O.

Tsitologiia 41(11): 975-991

1999

ISSN/ISBN: 0041-3771
PMID: 10643053
Document Number: 503537
This review presents literary data and results of the author own studies on structural and functional characteristics of regulatory (p55/p85) and catalytic (p110) subunits of heterodimeric phosphatidylinositol-3-kinases (PI-3-kinases), and on molecular mechanisms of their functional conjugation with other signaling system components, regulated by insulin and growth factors. Various models simulating the interaction of regulatory subunits of PI-3-kinase and of their substrates (insulin receptor sustrate proteins phosphorylated on tyrosin residues) with molecules of receptors-tyrosinekinases have been considered. Mechanisms of the functional conjugation between regulatory and catalytic enzyme subunits are discussed, with special reference to a possible role of the coiled-coil interactions in this process.

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