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Relation between mexidol glucuronide conjugation and characteristics of its therapeutic effect in patients with organic lesions in the central nervous system

Sariev, A.K.; Davydova, I.A.; Neznamov, G.G.; Zherdev, V.P.; Teleshova, E.S.

Eksperimental'naia i Klinicheskaia Farmakologiia 64(3): 17-21

2001

ISSN/ISBN: 0869-2092
PMID: 11558431
Document Number: 7506
The clinico-pharmacological and pharmacokinetic investigation of mexidole administered in patients with organic CNS damage showed for the first time that there is a correlation between intensity of the drug--glucurone conjugation and the parameters of psychopathological symptom expression and the individual patient state estimation before treatment and upon a single administration or a course of mexidole therapy. This correlation allows the clinico-pharmacological effects and the therapeutic efficacy of mexidole to be predicted based on the drug metabolism index.

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Relation between mexidol glucuronide conjugation and characteristics of its therapeutic effect in patients with organic lesions in the central nervous system

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