Gastric and duodenal features of meals mediate controls of liquid gastric emptying during fill in rhesus monkeys
Moran, T.H.; Knipp, S.; Schwartz, G.J.
American Journal of Physiology 277(5): R1282-R1290
1999
ISSN/ISBN: 0002-9513 PMID: 10564198 Document Number: 502112
Gastric emptying of liquid glucose was measured at various concentrations and volumes when administered intragastrically to rhesus monkeys at rates ranging from 12.5 to 37.5 ml/min. Glucose gastric emptying was faster during than following the period of gastric fill. At a single glucose concentration, volume infused rather than the rate of filling determined the volume emptied. Lower glucose concentrations emptied more slowly than physiological saline. As glucose concentration increased, emptying during fill slowed. Duodenal glucose infusions greatly slowed the rate of saline emptying during fill, demonstrating duodenal feedback control. Although casein hydrolysate emptied more rapidly than glucose, the dynamics of volume and concentration dependency and the role of duodenal feedback were similar.