Antipyretic, antiedematous and analgetic effects of damascenin in comparison with acetylsalicylic acid and phenylbutazone
Bekemeier, H.; Leuschner, G.; Schmollack, W.
Archives Internationales de Pharmacodynamie et de Therapie 168(1): 199-211
1967
ISSN/ISBN: 0003-9780 PMID: 6048725 Document Number: 5001
The acute p.o. LD 50 of Damascenin hydrochloride (3-methoxy-N-methyl-anthranilic acide mcthylester) in mice (6'; 16-zz g) amounts to i800 (16zo-zoto) mg/kg. Rats tolerated 1600 mg/kg p.o. without any symptoms. High i.v. doses caused embolism of the lungs because of separation of the oily base from the solution. Local irritation occurred after s.c. injection. 50 mg/kg of Damascenin i.p. depressed the normal and the enhanced body temperature of rats respectively guinea pigs; phenylbutazone was less active. The p.o. activity of Damascenin was low. Damascenin partially prevented formaline and dextran induced oedema of the rats paw; phenylbutazone and acetyl salicylic acid seemed less active. The antioedemous effect is not due to a diuretic action. Damascenin prevented the writhing-syndrome in mice provoked by i.p. application of o,3 % acetic acid. No analgesic action could be demonstrated by using an electric or heat stimulus.
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