Clinical effectiveness of a new vaginal contraceptive cream; a preliminary report
Behne, D.; Clark, F.; Jennings, M.; Pallais, V.; Olson, H.; Wolf, L.; Tyler, E.T.
Western Journal of Surgery Obstetrics and Gynecology 64(3): 152-157
1956
PMID: 13299945 Document Number: 499702
This preliminary report deals with a new contraceptive cream used without a diaphragm; its trade name is Delfen. A pilot study study was made with 24 patients for 3 months with no pregnancies or complications. Then 397 patients were started on this method; 227 continued from 3 to 18 months for a total of 2031 months. Patients were instructed in the method, supplies for 4-6 weeks were given, and patients told to return for further tubes of medication as needed. Postcoital examinations were done in 31 cases. In most cases no spermatozoa were found in cervical mucus and observed sperm had markedly diminished activity. Cervical biopsies and vaginal smears showed no irritation. Pregnancies occurred in 8 patients presumably using the method but in only 1 case had the cream always been used correctly and regularly. Conception occurred promptly after stopping the use of the cream in 3 patients who planned pregnancies. It was concluded that this contraceptive cream used along provided a highly satisfactory and acceptable method of conception control.