Nicotinamide in combined treatment of chronic pancreatitis
Loginov, A.S.; Matiushin, B.N.; Astaf'eva, O.V.; Nilova, T.V.; Vinokurova, L.V.
Terapevticheskii Arkhiv 71(8): 43-46
1999
ISSN/ISBN: 0040-3660 PMID: 10515036 Document Number: 499287
Aim. To evaluate effects of nicotinamide on insulin secretion in glucose tolerance test and on blood clotting in patients with chronic pancreatitis (CP). Materials and methods. 30 patients with CP of alcoholic etiology received combined treatment with enzyme medicines. In addition, some of them were administered nicotinamide as 2.5% solution for 2 weeks (1 ml twice a day). Before the treatment and during its course, measurements were made of fasting and post glucose test values of insulin secretion and thromboelastogram. Results. Both basal and stimulated insulin secretion in CP patients was low compared to control subjects. Nicotinamide significantly increased basal secretion of insulin and insignificantly aroused its glucose-stimulated secretion. Nicotinamide promoted reduction of hypercoagulation and time to remission. Conclusion. Nicotinainide administration is thought valid for correction of endocrine pancreatic function and hemocoagulation in patients with alcoholic CP.