Ancillary use of phenazopyridine (Pyridium) in urinary tract infections
Trickett, P.C.
Current Therapeutic Research 12(7): 441-445
1970
ISSN/ISBN: 0011-393X PMID: 4990290 Document Number: 4988
Ninety-eight subjects from a college health service were selected for a comparative study of the effects of phenazopyridine hydrochloride (Pyridium®) and methylene blue on acute urinary tract symptoms (nocturia, burning, urgency). The test substances were given as concomitant therapy to sulfonamides or antibiotics in many of the cases. Significantly more of the subjects given phenazopyridine showed an excellent response (28 out of 49, or 57 per cent) than in the group given methylene blue (2 of 51, or 3 per cent). The control group (given methylene blue) had the psychological benefit of colored urine, which has been described as the principal reason for the clinical effectiveness observed with phenazopyridine. This further equates the two groups for validity of symptomatic comparisons.
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