Autonomic nervous function of the patients with neurally mediated syncope
Saitoh, H.; Ono, T.; Nomura, A.; Iwasaki, Y.; Ohno, N.; Matsumoto, S.; Kobayashi, Y.; Atarashi, H.; Katoh, T.; Kishida, H.; Hayakawa, H.
Rinsho Byori. Japanese Journal of Clinical Pathology 46(10): 1043-1048
1998
ISSN/ISBN: 0047-1860 PMID: 9816917 Document Number: 496904
Although diagnosis of neurally mediated syncope (NMS) using head-up tilt (HUT) test has been established, the exact mechanism of NMS has not yet been elucidated. We evaluated beta and alpha-adrenergic function in NMS patients by pharmacological autonomic function test. The alpha-adrenergic sensitivity of NMS patients was significantly lower than that of control subjects. The patients who need low dose isoproterenol for provocation of syncope showed higher beta-adrenergic sensitivity than patients who developed syncope without isoproterenol. Thus, pharmacological autonomic function test was useful for evaluation of NMS patients.