Immunization of laboratory animals with ultraviolet-attenuated larvae against homologous challenge infection with Trichinella britovi
Nakayama, H.; Inaba, T.; Nargis, M.; Chisty, M.; Ito, M.; Kamiya, H.
Southeast Asian Journal of Tropical Medicine and Public Health 29(3): 563-566
1998
ISSN/ISBN: 0125-1562 PMID: 10437958 Document Number: 495915
Immunogenicity of Trichinella britovi (Japanese isolate, cord ISS 408) muscle larvae irradiated with 5 mJ/cm2 of short wavelength ultraviolet (UV) was studied using homologous challenge infections. SCID mice vaccinated with UV-attenuated larvae showed no resistance, although its congenic CB-17 mice exhibited remarkable immunity. Following challenge vaccinated Mongolian gerbils, Meriones unguiculatus, did not show significant immunity. Use of these animal models vaccinated with UV-attenuated larvae will contribute to the investigation of immune mechanisms against Trichinella infection and also to the development of a vaccine of trichinellosis.