Antidotal effect of grape juice (Vitis vinifera) on ochratoxin A caused hepatorenal carcinogenesis in mice (Mus musculus)
Jeswal, P.
Cytobios 93(373): 123-128
1998
ISSN/ISBN: 0011-4529 PMID: 9734345 Document Number: 495026
Oral administration of ochratoxin A (50 p.p.m.) to young weanling mice (M. musculus) caused several haematological changes and induced hepatoma and renal carcinoma. Concurrent administration of 1 ml berry and leaf juice of the common grape (Vitis vinifera) to mice together with ochratoxin A significantly reduced the hepatic and renal damage caused by ingestion of ochratoxin A. None of the animals receiving berry/leaf juice of V. vinifera showed the formation of hepatorenal carcinoma whereas 25% of animals receiving only ochratoxin A developed well differentiated renal carcinoma and hepatic lesions.