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Safety of bacteria of the genus Bacillus, forming the base of some probiotics

Osipova, I.G.; Sorokulova, I.B.; Tereshkina, N.V.; Grigor'eva, L.V.

Zhurnal Mikrobiologii Epidemiologii i Immunobiologii 6: 68-70

1998

ISSN/ISBN: 0372-9311
PMID: 9949507
Document Number: 494725
The study of the safety of bacillary strains forming the base of new probiotics (biosporin and subalin) was made. For control, the safety of Bacillus sp. IP5832 (the base of the preparation of bactisubtil) was studied. The results obtained in this investigation demonstrated that the strains contained in biosporin and subalin were safe when injected intravenously and intraperitoneally into animals in dose of 5 x 10(9) cells per 0.5 ml of physiological saline. The introduction of Bacillus sp. IP5832 in the same dose produced 100% lethal effect.

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