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Inhibition of beta-amyloid precursor protein gene expression by haifengteng

Han, E.; Rajiv, J.

Zhongguo Zhong Yao Za Zhi 23(11): 691

1998

ISSN/ISBN: 1001-5302
PMID: 11599352
Document Number: 494440
To study the inhibition of beta-amyloid precursor protein(beta-APP) gene expression by Haifengteng. Northern Blot analysis was used to investigate the level of beta-APP mRNA, and cell viability, LDH-release and colony formation assay were used to study the effect of Hairengteng of neurons. Haifengteng inhibited the expression of beta-APP gene selectively without causing cell injuries. beta-APP is closely related to Alzheimer's disease. The findings in this study could be a basis for Haifengteng to have therapeutic potentials in treating Alzheimer's disease.

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