Inhibition of melanogenesis as an adjuvant strategy in the treatment of melanotic melanomas: selective review and hypothesis
Slominski, A.; Paus, R.; Mihm, M.C.
Anticancer Research 18(5b): 3709-3715
1998
ISSN/ISBN: 0250-7005 PMID: 9854482 Document Number: 494198
Melanogenesis generates immunosuppressive and mutagenic environment and alters cellular metabolism. Melanin can protect malignant melanocytes against chemo-, radio-, and photodynamic therapy. Therefore, we propose to inhibit melanogenesis as an adjuvant treatment modality during immuno-, radio-, chemo- and photodynamic therapy, and as a measure of reducing the probability of melanoma progression.
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