Radiotherapy as local adjuvant treatment for endometrial carcinoma--a review of 45 patients
Lee, K.M.; Tan, H.S.; Leow, M.K.; Sethi, V.K.; Chua, E.J.
Annals of the Academy of Medicine Singapore 27(5): 636-639
1998
ISSN/ISBN: 0304-4602 PMID: 9919331 Document Number: 494976
Forty-five patients with endometrial carcinoma were treated with local postoperative adjuvant radiotherapy during the period 1992 to 1995. Radiotherapy technique comprised both external beam irradiation as well as high-dose-rate vaginal vault brachytherapy. The 5-year overall survival and relapse-free survival rates were 74% and 73%, respectively and poorly differentiated histology grade was associated with poorer prognosis. Only 1 patient developed an isolated vaginal vault recurrence and another 9 patients relapsed mainly at the distal anatomical sites. The main radiotherapy-related complications were vaginal adhesion and stenosis. Radiotherapy is therefore effective as local adjuvant treatment in reducing risk of local-regional relapse in endometrial carcinoma.