Prognostic factors in patients with cervical--confined endometrial carcinoma treated with surgery and postoperative radiotherapy
Karolewski, K.; Kojs, Z.; Jakubowicz, J.; Urbański, K.; Reinfuss, M.; Dymek, Pł.; Jóźwik, P.
Przeglad Lekarski 62(12): 1444-1446
2005
ISSN/ISBN: 0033-2240 PMID: 16786769 Document Number: 591915
The aim of the study was to determine prognostic factors in the group of the patients with uterine--confined endometrial carcinoma treated with surgery and postoperative radiotherapy. The authors analyzed 102 patients (mean age 58 years) with stage 1 (74 patients) and stage 11 (28 patients) endometrial carcinoma. All patients were treated with surgery (abdominal hysterectomy and bilateral adnexectomy) and postoperative radiotherapy: external beam pelvic irradiation (20 patients), vaginal cuff irradiation (33 patients) and combination (49 patients). Analysed were prognostic factors as follows: age, stage, tumor grade, depth of myometrial invasion, hormone receptors, expression of the tumor suppressor gene p53, Her 2/neu and MIB-1 (ki-67 paraffin). In our group of patients, multivariate analysis has identified tumor grade, progesterone receptors status and MIB-1 as independent significant prognostic factors.