Experimental model of renovascular hypertension
Cao, X.; He, N.; Wu, E.; Bai, J.; Yang, H.; Chang, J.
Chinese Medical Journal 111(5): 450-452
1998
ISSN/ISBN: 0366-6999 PMID: 10374357 Document Number: 493502
To establish a model of renovascular hypertension. A 4/0 resorbable chromic catgut ligature was used to ligate subtotally the renal arteries of 18 dogs, forming experimental renovascular hypertension steadily. Blood pressure, plasma renin activity, the ultrastructural changes of juxtaglomerular apparatus and renal artery wall were studied after the constriction. It was reasonable that renal blood flow measured with an electromagnetic flowmeter was reduced by 30% after the constriction. The pathological changes of the induced renal artery stenosis were similar to those of fibromuscular dysphasia. The findings provide valuable evidence for the treatment of renovascular hypertension.