Reactivation of renin secretion by a contralateral kidney in the chronic phase of experimental renovascular hypertension
Fedorov, V.I.
Kardiologiia 23(12): 65-70
1983
ISSN/ISBN: 0022-9040 PMID: 6366326 Document Number: 208437
When one renal artery is markedly narrowed, the renin-angiotensin system (RAS) is only suppressed at the initial stage of vasorenal hypertension in the contralateral kidney, and is reactivated during the chronic stage as manifested in normalized or increased total tissue content of active renin, its enhanced secretion and its activity in the outflowing blood. This kidney's RAS begins to have a prevailing effect on systemic RAS, while that of the ischemized kidney makes a smaller contribution. Similar changes can be observed in some animals with a moderately narrowed renal artery.