Expression of interleukin-8 in human glomerulonephritis
Sekikawa, T.; Kashihara, N.; Maruyama, K.; Satoh, M.; Okamoto, K.; Kanao, K.; Maeshima, Y.; Sugiyama, H.; Yamasaki, Y.; Makino, H.
Research Communications in Molecular Pathology and Pharmacology 99(2): 217-224
1998
ISSN/ISBN: 1078-0297 PMID: 9583095 Document Number: 493040
Interleukin-8 (IL-8) is a cytokine, which possesses both chemotactic and activating properties for neutrophils, lymphocytes and basophils. Various evidence has indicated IL-8 to be implicated in the pathophysiology of immune-mediated renal diseases. We thus examined the expression of IL-8 in renal diseases. We detected the expression of IL-8 both in mRNA and the protein levels in renal biopsy specimens obtained from patients with IgA nephropathy and lupus nephritis. A significant correlation was found between the expression of IL-8 mRNA and the number of neutrophils in the glomerulus. We also found a negative correlation between the expression of IL-8 mRNA and creatinine clearance. Our study thus suggested IL-8 to be involved in the pathophysiology of proliferative glomerulonephritis.