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In vitro studies on the influence of carbomers on the availability and acceptability of estradiol gels

Amsellem, E.; Derrien, F.; Lanquetin, M.; Paris, J.; Marty, J.P.

Arzneimittel-Forschung 48(5): 492-496

1998

ISSN/ISBN: 0004-4172
PMID: 9638317
Document Number: 491582
The objective of the present study was to evaluate the pharmaceutical properties of estradiol (CAS 50-28-2) gels: pH, viscosity, texture, spreadability, evaporation of solvent and transcutaneous diffusion from carbomer-based formulations. This study was performed with the aim of measuring possible pharmaceutical differences as a function of the nature of the polymers used. The results obtained show a similarity of behaviour for the Estreva gels made with carbomers Carbopol 1342 (C 1342) and 1382 (C 1382). The reference gel, commercially available in France and made with the carbomer Carbopol 934 (C 934) is different in terms of its theological criteria.

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In vitro studies on the influence of carbomers on the availability and acceptability of estradiol gels

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