The influence of nitrates on platelet oxygen metabolism: in vitro studies
Buczyński, A.; Dziedziczak-Buczyńska, M.; Gnitecki, W.; Kocur, J.
Polski Merkuriusz Lekarski Organ Polskiego Towarzystwa Lekarskiego 6(31): 15-17
1999
ISSN/ISBN: 1426-9686 PMID: 10344147 Document Number: 498819
Our investigations were carried out on human blood platelets obtained from persons aged 20-23, free from any systemic diseases. Drugs were incubated with blood platelets. Changes of antioxidant enzymes were detected. Glyceryl trinitrate increased the activity of Zn Cu-SOD (4.62%) and GPx (275.91%), concentration of ATP (13.01%) and the blood platelets aggregations (17.88%). Izosorbide dinitrate increased the activity of ZnCu-SOD (19.46%), GPx (150.36%) and Cat (15.62%), increased concentration of ATP (23.73%) and blood platelets aggregation (3.64%). Both preparats decreased concentration of MDA (Sustonit--30.79%, Iso-Mack--35.04%). Gliceryl trinitrate decreased the activity of catalase otherwise izosorbide dinitrate increased the activity of this enzyme.