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Involvement of interleukin-2 in analgesia produced by Coriolus versicolor polysaccharide peptides

Gong, S.; Zhang, H.Q.; Yin, W.P.; Yin, Q.Z.; Zhang, Y.; Gu, Z.L.; Qian, Z.M.; Tang, P.L.

Zhongguo Yao Li Xue Bao 19(1): 67-70

1998

ISSN/ISBN: 0253-9756
PMID: 10375763
Document Number: 491083
To study the role of interleukin-2 (IL-2) and mediobasal hypothalamus (MBH) in analgesia produced by Coriolus versicolor polysaccharide peptide (PSP). The IL-2 antiserum was injected i.c.v. or i.p. and the MBH was destroyed electrolytically. PSP i.g. 1 g.kg-1.d-1 for 6 d increased the pain threshold in tail stimulation-vocalization test in rats. This PSP-produced analgesia was blocked by i.c.v., but not i.p., IL-2 antiserum and disappeared after electrolytic lesion of MBH. The analgesia produced by PSP is mediated by IL-2 which is activated by PSP and interacts with IL-2 receptors in the MBH.

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