Association of elevated mutagenesis in the spleen with genetic susceptibility to induced plasmacytoma development in mice
Felix, K.; Kelliher, K.; Bornkamm, G.W.; Janz, S.
Cancer Research 58(8): 1616-1619
1998
ISSN/ISBN: 0008-5472 PMID: 9563470 Document Number: 489917
Using the phage lambdaLIZ-based transgenic in vivo mutagenesis assay, mean mutant rates were determined in the spleen of mice exposed to sustained oxidative stress and were found to be increased approximately 3-fold in plasmacytoma-susceptible BALB/c and C.D2-Idh1-Pep3 mice, but not in plasmacytoma-resistant DBA/2N mice. This finding suggests a correlation between the genetic susceptibility to inflammation-induced peritoneal plasmacytomagenesis and the phenotype of increased mutagenesis in lymphoid tissues, raising the possibility that plasmacytoma resistance genes may inhibit tumor development by minimizing oxidative mutagenesis in B cells.