Changes in the fractional collagen composition of the kidneys in rats under immobilization stress and alloxan diabetes
Trofimova, S.R.; Butolin, E.G.
Patologicheskaia fiziologiia i eksperimental'naia terapiia 1998(4): 27-28
1998
ISSN/ISBN: 0031-2991 PMID: 9951300 Document Number: 489253
Content of free hydroxyproline, total collagen and neutral salt-soluble, citrate-soluble, nonsoluble fractions of collagen and also collagenolytic activity on combined immobilization stress days 3, 10, 15 and 30 in alloxan diabetes were studied in homogenates of the cortical zone of rats' kidneys. Changes in the fractional collagen composition were found phasic. The additional stress load on its days 1-10 attenuates but in the following days aggravates the catabolic action of alloxan diabetes on collagen metabolism in the kidneys.