Wound healing around endosseous implants in experimental diabetes
Nevins, M.L.; Karimbux, N.Y.; Weber, H.P.; Giannobile, W.V.; Fiorellini, J.P.
International Journal of Oral and Maxillofacial Implants 13(5): 620-629
1998
ISSN/ISBN: 0882-2786 PMID: 9796145 Document Number: 489054
Wound healing has been shown to be altered in diabetes mellitus. The aim of this study was to identify the effects of streptozotocin-induced diabetes on osseointegration. Diabetes was induced in 40-day-old rats by intraperitoneal injection of 70 mg per kg streptozotocin. At 14 days postinjection, implants were placed in the femora of 10 diabetic and 10 age-matched normal rats. Animals were sacrificed at 28 and 56 days following implantation. Histometric results indicated that the quantity of bone formation was similar for diabetic and control animals (P > .05). However, less bone-implant contact was observed for diabetic compared to control animals at both 28 and 56 days (P < .0001). This study demonstrates that the process of osseointegration is affected by streptozotocin-induced diabetes.