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KY-62, a polyene analog of amphotericin B, for treatment of murine candidiasis

Graybill, J.R.; Najvar, L.K.; Fothergill, A.; Hardin, T.; Rinaldi, M.; Lambros, C.; Regen, S.L.

Antimicrobial Agents and Chemotherapy 42(1): 147-150

1998

ISSN/ISBN: 0066-4804
PMID: 9449275
Document Number: 488814
KY-62 is a water-soluble analog of amphotericin B. In vitro testing of five clinical isolates of Candida albicans showed KY-62 to have potency similar to that of amphotericin B. KY-62 was administered to mice infected intravenously with C. albicans. In vivo, KY-62 was effective in immunocompetent mice, with potency similar to that of amphotericin B. KY-62 was well tolerated up to 30 mg/kg of body weight per dose, an amount that would be lethal with amphotericin B. KY-62 was less effective in mice rendered neutropenic with 5-fluorouracil. The addition of flucytosine had little effect. KY-62 may have potential for clinical development.

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