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Isolation and identification of bromfenac glucoside from rat bile

Kirkman, S.K.; Zhang, M.Y.; Horwatt, P.M.; Scatina, J.

Drug Metabolism and Disposition the Biological Fate of Chemicals 26(7): 720-723

1998

ISSN/ISBN: 0090-9556
PMID: 9660857
Document Number: 488612
Bromfenac (Duract(R)), a drug approved for pain, was expected to be metabolized by the rat to an acyl glucuronide, a metabolite formed with most compounds of similar structure. During the investigation of metabolite profiles in rat bile following administration of 1 mg/kg iv doses of 14C-bromfenac, an acid-labile metabolite was found that degraded to form 14C-bromfenac. Isolation and characterization of this metabolite indicated that it is an unusual conjugate, bromfenac N-glucoside.

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