Central diabetes insipidus secondary to infundibuloneurohypophysitis
Isidro, M.L.; Martínez, A.; Argüeso, R.; Cordido, F.
Anales de Medicina Interna 15(12): 658-660
1998
ISSN/ISBN: 0212-7199 PMID: 9972603 Document Number: 488384
In up to a third of cases, central diabetes insipidus (DIC) is idiopathic although the percentage varies in different series. Since antibodies against magnicellular neurons were detected in some patients, a possible autoimmune basis for certain cases of apparently idiopathic DIC was speculated. Lymphocytic infundibuloneurohypophysitis, an inflammatory process that affects the infundibulum, pituitary stalk and neurohypophysis with distinctive radiologic, histologic and evolutive characteristics, has recently been described as a cause of central diabetes insipidus. We describe a patient in whom the clinical and radiologic characteristics suggest the diagnosis of DIC secondary to infundibuloneurohyphysitis.