Clinical evaluation of the effectiveness of radiotherapy for metastasis of cervical cancer to the vagina
Kanaev, S.V.; Turkevich, V.G.
Voprosy Onkologii 44(3): 325-329
1998
ISSN/ISBN: 0507-3758 PMID: 9695780 Document Number: 488214
The study presents an analysis of the data on 137 patients with cervical carcinoma metastases to the vagina (CCMV) treated with both combined (distance + contact) radiation and contact radiation alone administered in low, medium and high dose. Tumor response was evaluated on the basis of the following radiobiological modalities: time-dose-fractionation, cumulative radiation effect and linear-quadratic ("extrapolated dose of response"). The investigation established a correlation between survival and primary tumor stage rather than size of metastasis. There was no relationship between survival and the regime of therapy (combined or contact one alone). High-dose brachiatherapy proved to be the best component of intracavitary irradiation. There was no correlation between radiotherapy efficacy and regimen (surgery, combined therapy or radiation) in the management of primary cervical carcinoma.