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A case report of thyroid papillary cancer that manifested leukocytosis and hypercalcemia after radiotherapy in bone metastasis

Kobayashi, H.; Endo, K.; Nishimura, K.; Kasagi, K.; Yamamoto, I.; Konishi, J.; Abe, M.; Shimizu, Y.

Gan no Rinsho. Japan Journal of Cancer Clinics 35(1): 55-62

1989

ISSN/ISBN: 0021-4949
PMID: 2646465
Document Number: 332296
Bone metastasis from a thyroid papillary cancer of a 59-year-old woman had been successfully treated with radiotherapy (6,000 rad) and iodine-131 (120 mCi). One year later, the patient developed leukocytosis (maximum 143,000/mm3) and hypercalcemia (16.0 mg/dl). A colony stimulating factor (CSF) was detectable in her plasma, and nude mice that had been given metastatic tissues similarly developed leukocytosis and hypercalcemia. Leukocytosis and hypercalcemia seemed to have been caused by the CSF produced in the bone metastasized tissues of this thyroid cancer.

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