The antigenic characteristics of the viruses isolated from the cerebrospinal fluid of patients with epidemic neuropathy
Sarmiento Pérez, L.; Más Lago, P.; Avalos Redón, I.; Bello Corredor, M.; Palomera Puentes, R.
Revista Cubana de Medicina Tropical 50 Suppl: 231-234
1998
ISSN/ISBN: 0375-0760 PMID: 10349452 Document Number: 486143
During the epidemic of neuropathy occurred in Cuba from 1992 to 1994 viral agents antigenically related to the Coxsackie viruses were isolated from the cerebrospinal fluid of patients. To establish a function of these viruses in the etiopathogenesis of the disease, strains 47/93 IPK identified as Coxsackie A9 and the strain 44/93 of light cytopathic effect were selected to conduct a study of their antigenic characteristics by Western Blot. It was proved that there is an antigenic relationship between both strains and it was also demonstrated the absence of structural proteins in their native form among the agents of light cytopathic effect. According to these results, it is stated the possibility that persistence may be a mechanism through which these viruses take part in the etiopathogenesis of epidemic neuropathy in Cuba.