Embryonic lethality and tumorigenesis caused by segmental aneuploidy on mouse chromosome 11
Liu, P.; Zhang, H.; McLellan, A.; Vogel, H.; Bradley, A.
Genetics 150(3): 1155-1168
1998
ISSN/ISBN: 0016-6731 PMID: 9799267 Document Number: 484829
Chromosome engineering in mice enables the construction of models of human chromosomal diseases and provides key reagents for genetic studies. To begin to define functional information for a small portion of chromosome 11, deficiencies, duplications, and inversions were constructed in embryonic stem cells with sizes ranging from 1 Mb to 22 cM. Two deficiencies and three duplications were established in the mouse germline. Mice with a 1-Mb duplication developed corneal hyperplasia and thymic tumors, while two different 3- to 4-cM deficiencies were embryonically lethal in heterozygous mice. A duplication corresponding to one of these two deficiencies was able to rescue its haplolethality.