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Protection of ebselen against anoxic damage of cultured neurons of cerebral cortex

Tan, Y.X.; Li, W.H.; Tao, X.B.; Jiang, Y.Y.; Chen, W.P.; Zhou, B.

Zhongguo Yao Li Xue Bao 18(3): 201-203

1997

ISSN/ISBN: 0253-9756
PMID: 10072932
Document Number: 481754
AIM: To study the protective effect of ebselen on anoxic damage of brain cells. METHODS: On d 10 after plating of the cortical neurons from 1-d-old rat, cultures were placed under 95% N-2 + 5% CO-2 for 2-6 h. Lactate dehydrogenase (LDH) in supernatant, thiobarbituric acid reactive substance (TBARS) and glutathione peroxidase (GSH-Px) activity of neurons were determined. RESULTS: Under anoxia, efflux of LDH and TBARS from cultured neurons increased while GSH-Px activity decreased. Ebselen reduced the efflux of LDH and TBARs in a dose-related manner and increased the total GsH-Px activity. CONCLUSION: Ebselen can protect neurons from anoxic damage.

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