Cytokines in experimental acute pancreatitis
Márton, J.; Farkas, G.; Nagy, Z.; Takács, T.; Jármay, K.; Varga, J.; Balogh, A.
Orvosi Hetilap 138(12): 739-742
1997
ISSN/ISBN: 0030-6002 PMID: 9157344 Document Number: 480565
Cytokines in experimental acute pancreatitis. The authors induced acute necrotizing pancreatitis in Wistar rat by intraductal injekciton of taurocholic acid (150 mu-l or 200 mu-l 6%). Plasma values of amylase, TNF, IL-6 levels and wet pancreas weight/body weight ratio have been determined. Histologic analysis of pancreas proved severe acute necrotizing pancreatitis with microabscess formation and beginning respiratory distress syndrome was observed in the lungs. TNF and IL-6 levels increased significantly after administration of 200 mu-l 6% taurocholic acid. The authors emphasise the importance of cytokines in the development of acute necrotizing pancreatitis.