Top Abstract Purchase Related
Home
>
Node
>
Subnode

ATP-dependent glutathione conjugate export pump

Furukawa, T.; Chen, Z.S.; Akiyama, S.

Nihon Rinsho. Japanese Journal of Clinical Medicine 55(5): 1083-1090

1997

ISSN/ISBN: 0047-1852
PMID: 9155157
Document Number: 480111
KCP4 cells are resistant to cisplatin and have a GS-X pump different from MRP. The GS-X pump was suggested to be involved in reducing the accumulation of cisplatin in KCP-4 cells. The expression of cMOAT was 4-to 6-fold higher in KCP-4 cells and two other cisplatin-resistant human cell lines. It is still not clear whether the cisplatin resistance in KCP-4 cells are attributed to cMOAT. Other members of the MRP/GS-X pump family have been reported. Amino acid sequence of EBCR of rabbit is 91% identical to that of human cMOAT. On the view of cancer chemotherapy, it is very important to understand the structure and function of GS-X pumps since they may be involved in not only drug resistance but also drug metabolism and side effects.

Document emailed within 1 workday
Secure & encrypted payments

Paranka, N.S.; Dorr, R.T. 1994: Effect of doxorubicin on glutathione and glutathione-dependent enzymes in cultured rat heart cells Anticancer Research 14(5a): 2047-2052
Shore, L.J.; Fenselau, C.; King, A.R.; Dickinson, R.G. 1995: Characterization and formation of the glutathione conjugate of clofibric acid Drug Metabolism and Disposition: the Biological Fate of Chemicals 23(1): 119-123
Gouyette, A.; Voisin, E.; Auclair, C.; Paoletti, C. 1987: Isolation and characterization of the glutathione-elliptinium conjugate in human urine Anticancer Research 7(4b): 823-827
Monks, T.J.; Lau, S.S. 1987: Renal transport processes and glutathione conjugate-mediated nephrotoxicity Drug Metabolism and Disposition: the Biological Fate of Chemicals 15(4): 437-441
Snel, C.A.; Moons, M.M.; Russel, F.G.; Mulder, G.J. 1995: Disposition of the bromosulfophthalein-glutathione conjugate in the isolated perfused rat kidney Journal of pharmacology and experimental therapeutics 273(3): 1300-1306
Hutson, D.H.; Logan, C.J.; Regan, P.D. 1984: Evidence for the formation of a novel glutathione conjugate in the metabolism of an aromatic amine derivative Drug Metabolism and Disposition: the Biological Fate of Chemicals 12(4): 523-524
Weidemann, G.; Anselstetter, V. 1977: Multiple forms of NADPH-dependent glutathione reductase in serum. Studies on the NADPH-dependent glutathione-reductase in serum Ii Journal of Clinical Chemistry and Clinical Biochemistry 15(8): 411-417
Ishizuka, T.; Komiya, I.; Hiratsuka, A.; Watabe, T. 1990: Novel type of ornithine-glutathione double conjugate excreted as a major metabolite into the bile of rats administered clebopride Molecular Pharmacology 37(6): 983-989
Dygas, A.; Makowski, P.; Pikuła, S. 1998: Is the glutathione conjugate of trans-4-hydroxy-2-nonenal transported by the multispecific organic anion transporting-ATPase of human erythrocytes? Acta Biochimica Polonica 45(1): 59-65
Funk, C.; Ponelle, C.; Scheuermann, G.; Pantze, M. 2001: Cholestatic potential of troglitazone as a possible factor contributing to troglitazone-induced hepatotoxicity: in vivo and in vitro interaction at the canalicular bile salt export pump (Bsep) in the rat Molecular Pharmacology 59(3): 627-635
Jordan L. Holtzman 2002: The Role of Low Levels of the Serum Glutathione-Dependent Peroxidase and Glutathione and High Levels of Serum Homocysteine in the Development of Cardiovascular Disease Clinical Laboratory 48(3-4): 129-130
Thomson, C.D. 1985: Selenium-dependent and non-selenium-dependent glutathione peroxidase in human tissues of New Zealand residents Biochemistry International 10(4): 673-679
Ibrahim, S.A.; Balasubramanian, K.A. 1991: Glutathione-dependent fatty acylprotein deacylase Biochemistry International 24(4): 595-604
Vella, P.P.; Staub, J.M.; Armstrong, J.; Dolan, K.T.; Rusk, C.M.; Szymanski, S.; Greer, W.E.; Marburg, S.; Kniskern, P.J.; Schofield, T.L. 1990: Immunogenicity of a new Haemophilus influenzae type b conjugate vaccine (meningococcal protein conjugate) (PedvaxHIB) Pediatrics 85(4 Part 2): 668-675
Gavriliuk, L.A.; Shevchenko, N.V.; Spineĭ, A.F.; Vartichan, A.I.; Godorozha, P.D.; Lysyĭ, L.T. 2008: Activity of salivary glutathione-dependent enzymes in patients with periodontitis Klinicheskaia Laboratornaia Diagnostika 7: 22-26
Punekar, N.S.; Lardy, H.A. 1989: Glutathione peroxidase and iron-thiol dependent lipid peroxidation Biochemistry International 19(6): 1381-1386
Olsson, U. 1990: Glutathione-dependent and ketone body-related enzymes in the selenium-deficient rat International Journal for Vitamin and Nutrition Research. Internationale Zeitschrift für Vitamin- und Ernahrungsforschung. Journal International de Vitaminologie et de Nutrition 60(1): 89-94
Ghijsen, W.E.; Van Os, C.H.; Heizmann, C.W.; Murer, H. 1986: Regulation of duodenal Ca2+ pump by calmodulin and vitamin D-dependent Ca2+-binding protein American Journal of Physiology 251(2 Pt 1): G223-G229
Lash, L.H.; Qian, W.; Putt, D.A.; Jacobs, K.; Elfarra, A.A.; Krause, R.J.; Parker, J.C. 1998: Glutathione conjugation of trichloroethylene in rats and mice: sex-, species-, and tissue-dependent differences Drug Metabolism and Disposition: the Biological Fate of Chemicals 26(1): 12-19
Sergeev, P.V.; Chukaev, S.A.; Korovkina, I.A. 1997: Effect of sex hormones and antihormones on the activity of glutathione-dependent redox enzymes of human erythrocytes Biulleten' Eksperimental'noi Biologii i Meditsiny 124(8): 185-187