Glutathione-dependent and ketone body-related enzymes in the selenium-deficient rat
Olsson, U.
International Journal for Vitamin and Nutrition Research. Internationale Zeitschrift für Vitamin- und Ernahrungsforschung. Journal International de Vitaminologie et de Nutrition 60(1): 89-94
1990
ISSN/ISBN: 0300-9831 PMID: 1974890 Document Number: 358291
Male rats, born of selenium (Se)-depleted dams and continously fed a Se-deficient diet regimen or Se-repleted for 11 weeks, were used for some enzymatic determinations in samples from liver, heart, kidney and hind limb muscle. The Se-dependent GSH-Px activity in liver and kidney of the Se-deficient group was less than 0.5% of Se-repleted controls, whereas a 3-fold increase in liver and kidney GSH S-transferase activity was found in these Se-deficient rats. The Se-deficient group excreted 3 times more acetoacetate via the urine than their Se-repleted sieblings. The activity of the key enzymes of ketone body utilization was similar in tissues from Se-repleted and Se-deficient rats. It is suggested that longlasting or even Se-unresponsive changes in enzymes of ketone body metabolism might have developed in these rats born of Se-depleted dams.