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Glutathione and related enzymes in fascioliasis before and after treatment with bithionol

Abdel-Rahman, S.Z.; el-Sharkawy, A.M.; Abou-Bacha, L.M.; Salem, A.

Journal of Tropical Medicine and Hygiene 93(5): 337-340

1990

ISSN/ISBN: 0022-5304
PMID: 1977927
Document Number: 362810
The present work is an update evaluation of the glutathione status in patients with established fascioliasis before and after treatment with bithionol. Blood glutathione (GSH), erythrocyte glutathione S-transferase (GST) and serum .gamma.-glutamyl transferase (GGT) activities were studied. After treatment, the variations observed in these parameters were restored to the corresponding normal control values confirming the toxic features resulting from fascioliasis and suggesting no adverse effect of bithionol on the parameters studied. We recommend the use of serum GGT, blood GSH and erythrocyte GST for the early detection of therapeutic response in fascioliasis.

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