Isolation and characterization of the glutathione-elliptinium conjugate in human urine
Gouyette, A.; Voisin, E.; Auclair, C.; Paoletti, C.
Anticancer Research 7(4b): 823-827
1987
ISSN/ISBN: 0250-7005 PMID: 3674767 Document Number: 293084
In a cancer patient given 100 mg/m2 elliptinium by intravenous infusion, the glutathione conjugate was found in urine. This metabolite was isolated after ion-exchange treatment and high performance liquid chromatography. Its structure was assessed by fast-atom bombardment mass spectrometry and comparison with an authentic sample.
Document emailed within 1 workday
Related Documents
Shore, L.J.; Fenselau, C.; King, A.R.; Dickinson, R.G. 1995: Characterization and formation of the glutathione conjugate of clofibric acid Drug Metabolism and Disposition: the Biological Fate of Chemicals 23(1): 119-123De Angelis, C.; Riscazzi, M.; Salvini, R.; Piccoli, A.; Ferri, C.; Santucci, A. 1997: Isolation and characterization of a digoxin-like immunoreactive substance from human urine by affinity chromatography Clinical Chemistry 43(8 Pt 1): 1416-1420
Hignite, C.E.; Tschanz, C.; Huffman, D.H.; Azarnoff, D.L. 1978: Quantitation of N-demethylantipyrine in biological samples and isolation and characterization of its glucuronic acid conjugate Drug Metabolism and Disposition: the Biological Fate of Chemicals 6(3): 288-295
Dygas, A.; Makowski, P.; Pikuła, S. 1998: Is the glutathione conjugate of trans-4-hydroxy-2-nonenal transported by the multispecific organic anion transporting-ATPase of human erythrocytes? Acta Biochimica Polonica 45(1): 59-65
Hui, C.-Y.; Guo, Y.; Zhang, W.; Yang, X.-Q.; Gao, C.-X.; Yang, X.-Y. 2017: Isolation and characterization of antimicrobial peptides from healthy male urine Pakistan Journal of Pharmaceutical Sciences 30(2): 363-367
Lash, L.H.; Nelson, R.M.; Van Dyke, R.A.; Anders, M.W. 1990: Purification and characterization of human kidney cytosolic cysteine conjugate beta-lyase activity Drug Metabolism and Disposition: the Biological Fate of Chemicals 18(1): 50-54
Cryz, S.J.; Sadoff, J.C.; Ohman, D.; Fürer, E. 1988: Characterization of the human immune response to a Pseudomonas aeruginosa O-polysaccharide-toxin a conjugate vaccine Journal of Laboratory and Clinical Medicine 111(6): 701-707
Del Boccio, G.; Di Ilio, C.; Casalone, E.; Pennelli, A.; Aceto, A.; Sacchetta, P.; Federici, G. 1987: Purification and characterization of glutathione transferase of human thyroid Italian Journal of Biochemistry 36(1): 8-17
Furukawa, T.; Chen, Z.S.; Akiyama, S. 1997: ATP-dependent glutathione conjugate export pump Nihon Rinsho. Japanese Journal of Clinical Medicine 55(5): 1083-1090
Seon, B.K.; Yoshizaki, K.; Pressman, D. 1979: Detection and characterization of human leukemia-associated antigens on leukemic cell lines and thymocytes. II. Isolation of human thymus-leukemia-associated antigens from the cell surface and partial characterization Journal of Immunology 122(5): 1951-1959
Snel, C.A.; Moons, M.M.; Russel, F.G.; Mulder, G.J. 1995: Disposition of the bromosulfophthalein-glutathione conjugate in the isolated perfused rat kidney Journal of pharmacology and experimental therapeutics 273(3): 1300-1306
Monks, T.J.; Lau, S.S. 1987: Renal transport processes and glutathione conjugate-mediated nephrotoxicity Drug Metabolism and Disposition: the Biological Fate of Chemicals 15(4): 437-441
Schröder, H.; Schröder, B.M. 1973: Isolation and determination of a hydroxylated metabolite of sulphapyridine from human urine Acta Pharmaceutica Suecica 10(4): 263-268
Norpoth, K.; Müller, G.; Raidt, H. 1976: Isolation and characterisation of two main metabolites of ifosfamide from human urine Arzneimittel-Forschung 26(7): 1376-1377
Hutson, D.H.; Logan, C.J.; Regan, P.D. 1984: Evidence for the formation of a novel glutathione conjugate in the metabolism of an aromatic amine derivative Drug Metabolism and Disposition: the Biological Fate of Chemicals 12(4): 523-524
Cmarik, J.L.; Inskeep, P.B.; Meredith, M.J.; Meyer, D.J.; Ketterer, B.; Guengerich, F.P. 1990: Selectivity of rat and human glutathione S-transferases in activation of ethylene dibromide by glutathione conjugation and DNA binding and induction of unscheduled DNA synthesis in human hepatocytes Cancer Research 50(9): 2747-2752
Halkin, O.I.; Savchenko, A.A.; Nikitina, K.I.; Duhan, O.M. 2013: Isolation and characterization of new monoclonal antibodies against human IgE Ukrains'kyi Biokhimichnyi Zhurnal 85(5): 81-87
Billing, R.J.; Safani, M.; Peterson, P. 1976: Isolation and characterization of human B cell alloantigens Journal of Immunology 117(5 Part 1): 1589-1593
Vanduffel, L.; Peeters, B.; Rombauts, W. 1973: Isolation and characterization of human ribosomal subunits Archives Internationales de Physiologie et de Biochimie 81(2): 392-393
Peters, W.H.; Roelofs, H.M. 1992: Biochemical characterization of resistance to mitoxantrone and adriamycin in Caco-2 human colon adenocarcinoma cells: a possible role for glutathione S-transferases Cancer Research 52(7): 1886-1890