Inhibitory effects of seven organosulphur compounds on clinical isolates of Candida species in vitro
Shah, D.T.; Walker, E.M.; Jones, M.M.; Singh, P.K.; Larsen, B.
Annals of Clinical and Laboratory Science 27(4): 282-286
1997
ISSN/ISBN: 0091-7370 PMID: 9210973 Document Number: 477807
Thirty clinical isolates of Candida albicans and 10 other Candida species were tested for susceptibility to 6 substituted dithiocarbamates and one dimercaptosuccinate. Dimethyldithiocarbamate, sodium pyrrolidine dithiocarbamate, and sodium diethyldithiocarbamate showed dose-dependent antifungal activity which was partially reversed by the addition of zinc, copper, or iron sulfate with greatest reversal at 2:1 metal to dithiocarbamate molar ratio. Anaerobiosis also interfered with dithiocarbamate antifungal activity.
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