"Multicore" myopathy: report of 5 cases
Miró, O.; Cebrián, M.; Laguno, M.; Pedrol, E.; Casademont, J.; Grau, J.M.
Medicina Clinica 108(19): 739-743
1997
ISSN/ISBN: 0025-7753 PMID: 9324599 Document Number: 474673
Five cases (three of them from a same family) of multicore myopathy are presented. The age at diagnosis ranged from 4 to 38 years. In 2 cases muscle complaints developed early in childhood while in the remaining 3 cases raised CK serum levels lead to perform a muscle biopsy. Malignant hyperthermia occurred in a young boy among the three affected relatives. Other family members are probably affected, suggesting an autosomal dominant inheritance. In none of the patients progressive disabling myopathy has occurred after a long term follow-up. A review of the bibliography is included, and clinical and evolutive characteristics of this myopathy are commented.