Chronic pseudo-hypertrophic myopathy in sarcoidosis. Apropos of 3 cases
Bekada-Alidieres, N.; Thibault, J.L.; Gherardi, R.; Tazi, A.; Sadoun, D.; Carvaillo, D.; Tandjaoui, H.; Battesti, J.P.; Delaporte, P.
Annales de Medecine Interne 149(3): 115-119
1998
ISSN/ISBN: 0003-410X PMID: 11490532 Document Number: 488864
We report three cases of pseudohypertrophic chronic myopathy in patients with sarcoidosis. The patients were aged 41-50 years and were of African or mixed ethnic origin. All three patients had multiorgan sarcoidosis recently diagnosed by the presence of hiliary and/or mediastinal node enlargement with or without reticulomicronodulation in the lung fields. Hypertrophy of the proximal portion of the limbs dominated the clinical presentation. In 2 cases, the myopathy was preceded by myalgia and in 2 cases associated with muscle nodules. The muscle enzymes were elevated in 2 cases. The importance of tuberculoid granulomas and the discretion of the myopathy characterised the histological findings in all 3 cases. Cortisone therapy was given early and long-term treatment led to favorable course in 2 cases, probably due to the importance of the granulomatous muscle mass. In the third case, peripheral neuropathy developed.